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CCB Seminar: Evolutionary forces shape the genetic architecture of complex traits
March 2 @ 3:00 pm - 4:00 pm
Dr. Ryan Hernandez, UCSF
Talk will also be broadcast via Zoom: https://berkeley.zoom.us/j/99535189861
Human evolutionary history has included waves of migration across the world, substantial population bottlenecks, and super exponential growth. Humans have also experienced rapid adaptation to novel environments and pathogens, as well as the relentless force of purifying selection purging deleterious mutations. While these evolutionary forces are known to impact local and genomic patterns of genetic variation, their impact on the genetic architecture of complex traits is less well established. Here I present some ideas on the relationship between evolutionary forces and the genetic architecture of complex traits. I then discuss how recent population dynamics in Hispanic/Latiné populations have shaped patterns of ancestry in these populations, with implications for how dynamic patterns of complex traits might emerge.
Ryan Hernandez is a Professor in the Department of Bioengineering and Therapeutic Sciences at UCSF. He is the Director of the Biological and Medical Informatics graduate program, the Director of the Initiative for Digital Transformation at UCSF, and the co-Director for the Postbaccalaureate Research Opportunities to Promote Equity in Learning (PROPEL) training program. His research focuses on population genetics, and using evolutionary modeling to understand complex biological patterns.