CCB faculty Nir Yosef and colleagues, including co-first authors Dian Yang and Matthew G. Jones, recently published a research article describing the patterns of tumor evolution in a mouse model of lung adenocarcinoma. Using advanced lineage tracing technology and single-cell sequencing assays, they profiled the changes that tumors undergo as they grow from a single, transformed cell into an aggressive, metastatic tumor at unprecedented resolution. They hope that these systems they have developed can enable future investigations and that the findings might inform how cancer progression can be better managed in the clinic.
The article can be found here.
